Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes.
نویسندگان
چکیده
Time is of the essence: The rotational motion of biomolecules depends on intra- and intermolecular interactions and thus on distinct functional states. A new method, called HYCUD accurately predicts rotational correlation times in complex dynamic systems. It gives insights into the motional behavior of multidomain proteins in their free form and in supramolecular complexes.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 43 شماره
صفحات -
تاریخ انتشار 2013